Vol. 142, No. 47 — November 22, 2008

GOVERNMENT NOTICES

DEPARTMENT OF THE ENVIRONMENT

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999

Significant New Activity Notice No. 15278

Significant New Activity Notice

(Section 85 of the Canadian Environmental
Protection Act, 1999)

Whereas the Minister of the Environment and the Minister of Health have assessed information in respect of the substance Alkanes, C_14-16, Chemical Abstracts Service Registry No. 90622-46-1;

Whereas the substance is not on the Domestic Substances List;

And whereas the Ministers suspect that a significant new activity in relation to the substance may result in the substance becoming toxic under the Canadian Environmental Protection Act, 1999,

Therefore, the Minister of the Environment indicates, pursuant to section 85 of that Act, that subsection 81(4) of the same Act applies with respect to the substance in accordance with the Annex.

JOHN BAIRD
Minister of the Environment

ANNEX

Information Requirements

(Section 85 of the Canadian Environmental
Protection Act, 1999)

1. In relation to the substance Alkanes, C_14-16, a significant new activity is the use of the substance in Canada, in any quantity, as a component of personal care products.

2. A person who proposes a significant new activity set out in this Notice for this substance shall provide to the Minister of the Environment, at least 90 days prior to the commencement of the proposed significant new activity, the following information:

(a) a description of the proposed significant new activity in relation to the substance;

(b) the information specified in Schedule 4 of the New Substances Notification Regulations (Chemicals and Polymers);

(c) the information specified in item 8 of Schedule 5 to those Regulations;

(d) the information specified in item 11 of Schedule 6 to those Regulations; and

(e) data from a test investigating skin tumour promotion (e.g. mouse skin tumour assay) in respect of the substance.

3. The above information will be assessed within 90 days after the day on which it is received by the Minister of the Environment.

EXPLANATORY NOTE

(This explanatory note is not part of the
Significant New Activity Notice.)

A Significant New Activity Notice is a legal instrument issued by the Minister of the Environment pursuant to section 85 of the Canadian Environmental Protection Act, 1999. The Significant New Activity Notice sets out the appropriate information that must be provided to the Minister for assessment prior to the commencement of a new activity as described in the Notice.

Substances that are not listed on the Domestic Substances List can be manufactured or imported only by the person who has met the requirements set out in section 81 of the Canadian Environmental Protection Act, 1999. Under section 86 of the Canadian Environmental Protection Act, 1999, in circumstances where a Significant New Activity Notice is issued for a new substance, it is the responsibility of every person who transfers the physical possession or control of the substance to notify all persons to whom the possession or control is transferred of the obligation to comply with the Significant New Activity Notice and of the obligation to notify the Minister of the Environment of any new activity and all other information as described in the Notice. It is the responsibility of the users of the substance to be aware of and comply with the Significant New Activity Notice and to submit a Significant New Activity notification to the Minister prior to the commencement of a significant new activity associated with the substance. However, as mentioned in subsection 81(6) of the Canadian Environmental Protection Act, 1999, a Significant New Activity notification is not required when the proposed new activity is regulated under an Act or regulations listed on Schedule 2 of the Canadian Environmental Protection Act, 1999.

A Significant New Activity Notice does not constitute an endorsement from Environment Canada of the substance to which it relates, or an exemption from any other laws or regulations that are in force in Canada and that may apply to this substance or activities involving the substance.

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DEPARTMENT OF HEALTH

CONTROLLED DRUGS AND SUBSTANCES ACT

Notice to interested parties — Proposal regarding the addition of substances to the schedules to the Controlled Drugs and Substances Act

This notice provides interested stakeholders with the opportunity to provide preliminary comments on Health Canada’s proposal to add a series of benzyl/phenyl piperazine derivatives to the schedules to the Controlled Drugs and Substances Act (CDSA), and to identify themselves for inclusion in any future consultation.

The substances under consideration are

• 1-(Phenylmethyl)piperazine (BZP) and its salts
• 1-Methyl-4-(phenylmethyl)piperazine (MBZP) and its salts
• 1,4-Bis(phenylmethyl)piperazine (DBZP) and its salts
• 1-(1,3-Benzodioxol-5-methyl)piperazine (MDBZP) and its salts
• 1-(3-Trifluoromethylphenyl)piperazine (TFMPP) and its salts
• 1-(4-Fluorophenyl)piperazine (pFPP) and its salts
• 1-(4-Methoxyphenyl)piperazine (MeOPP) and its salts
• 1-(3-Chlorophenyl)piperazine (mCPP) and its salts

Piperazines are a class of compounds with many industrial and pharmaceutical uses. The substances listed above are piperazine derivatives that are characterized by the presence of a benzyl group or phenyl group on the piperazine molecule. None of these substances are currently included in any of the schedules to the CDSA, nor have any been approved as drugs under the Food and Drugs Act. Health Canada is not aware that any of these substances are used commercially in the production of any industrial or pharmaceutical products in Canada.

Health Canada has become aware that these substances are increasingly being used recreationally for their stimulant and hallucinogenic properties. Pills containing these substances have increasingly been seen on the Canadian rave and party scene and are often advertised as “natural” or “legal” alternatives to MDMA (ecstasy). These types of pills are readily available for sale in specialty retail outlets (head shops, sex shops, etc.) and on the Internet. Health Canada has also noted a steady increase in the number of shipments of large quantities of some of these substances coming into Canada in both pill and bulk powder form.

These substances produce similar effects to those of amphetamines and MDMA and their effects on the human body may be compounded when taken with alcohol and other drugs. In particular, the scientific literature includes reports indicating the toxicity associated with the use of these pills in other countries. For example, a study conducted in a New Zealand hospital over a five-month period indicated that 61 patients presented themselves to emergency rooms because of adverse reactions associated with the use of BZP-based pills. While these reactions ranged from mild to moderate, two patients experienced life-threatening toxicity. There have also been two deaths reported in the literature, involving the combination use of BZP and other substances. Health Canada is thus concerned that these substances pose a risk to the health and safety of Canadians and is therefore considering regulating them as controlled substances.

Although these substances are not currently included in any of the United Nations drug control conventions, a number of countries have chosen to regulate some of them as controlled substances. For example, the United States, New Zealand, Australia, Belgium, and Denmark have all made the decision to regulate BZP as a controlled substance, while in New Zealand, TFMPP, pFPP, MeOPP, mCPP and MBZP are also regulated as controlled substances under the Misuse of Drugs Act.

Placing these substances within the scope of the CDSA may prohibit any or all of the following activities with these substances unless authorized by regulation: possession, trafficking, possession for the purpose of trafficking, importation, exportation, possession for the purpose of exportation, and production.

As this action is not intended to interfere with the legitimate use and availability of any piperazine compounds or derivatives with any legitimate medical or industrial purpose, Health Canada is seeking information from stakeholders on whether there are any legitimate industrial or medical uses for these aforementioned substances in Canada. Information received in response to this notice will be instrumental in determining appropriate scheduling under the CDSA.

The publication of this notice begins a 30-day comment period. There will be additional opportunities to provide comments following prepublication of a proposed regulatory amendment in the Canada Gazette, Part I. This is expected to take place in 2009.

If you are interested in this process or have comments on this proposal, please contact Elizabeth Dussault, Policy and Regulatory Affairs Division, Office of Controlled Substances, Address Locator 3503D, 123 Slater Street, Ottawa, Ontario, Canada K1A 1B9, by fax at 613-946-4224 or by email at OCS_Policy_and_ Regulatory_Affairs@hc-sc.gc.ca.

November 14, 2008

RAY EDWARDS
Acting Director General
Drug Strategy and Controlled
Substances Directorate

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DEPARTMENT OF HUMAN RESOURCES AND SKILLS DEVELOPMENT

EMPLOYMENT INSURANCE ACT

Resolution

DEPARTMENT OF INDUSTRY

OFFICE OF THE REGISTRAR GENERAL

Appointments

Name and position

Instrument of Advice dated October 30, 2008

Ablonczy, The Hon. Diane, P.C.

Minister of State to assist the Minister of Industry to be styled Minister of State — Small Business and Tourism

Aglukkaq, Leona, P.C.

Minister of Health

Ambrose, The Hon. Rona, P.C.

Minister of Labour

Ashfield, Keith, P.C.

Minister of State to assist the Minister for the purposes of the Atlantic Canada Opportunities Agency Act to be styled Minister of State — Atlantic Canada Opportunities Agency

Baird, The Hon. John, P.C.

Minister of Transport to be styled Minister of Transport, Infrastructure and Communities

Blackburn, The Hon. Jean-Pierre, P.C.

Minister of National Revenue and Minister of State to assist the Minister of Agriculture and Agri-food to be styled Minister of National Revenue and Minister of State — Agriculture

Cannon, The Hon. Lawrence, P.C.

Minister of Foreign Affairs and Minister of State to assist the Minister of Transport — National Capital Commission to be styled Minister of Foreign Affairs

Clement, The Hon. Tony, P.C.

Minister of Industry

Day, The Hon. Stockwell, P.C.

Minister for International Trade and Minister of State to assist the Minister of Transport to be styled Minister of International Trade and Minister for the Asia-Pacific Gateway

Finley, The Hon. Diane, P.C.

Minister of Human Resources and Skills Development

Flaherty, The Hon. James Michael, P.C.

Minister of Finance

Fletcher, Steven John, P.C.

Minister of State to assist the Prime Minister to be styled Minister of State — Democratic Reform

Goodyear, Gary, P.C.

Minister of State to assist the Minister of Industry to be styled Minister of State — Science and Technology

Guergis, The Hon. Helena, P.C.

Minister of State to assist the Minister of Canadian Heritage to be styled Minister of State — Status of Women

Hill, The Hon. Jay D., P.C.

Leader of the Government in the House of Commons

Kenney, The Hon. Jason, P.C.

Minister of Citizenship and Immigration to be styled Minister of Citizenship, Immigration and Multiculturalism

Kent, Peter, P.C.

Minister of State to assist the Minister of Foreign Affairs to be styled Minister of State of Foreign Affairs — Americas

Lebel, Denis, P.C.

Minister of State to assist the Minister of the Economic Development Agency of Canada for the Regions of Quebec to be styled Minister of State — Economic Development Agency of Canada for the Regions of Quebec

LeBreton, The Hon. Marjory, P.C.

Leader of the Government in the Senate and Minister of State to assist the Minister of Human Resources and Skills Development to be styled Leader of the Government in the Senate and Minister of State — Seniors

Lunn, The Hon. Gary, P.C.

Minister of State to assist the Minister of Canadian Heritage to be styled Minister of State — Sport

MacKay, The Hon. Peter Gordon, P.C.

Minister of National Defence, Minister for the purposes of the Atlantic Canada Opportunities Agency Act and Minister of State to assist the Minister of Transport to be styled Minister of National Defence and Minister of the Altantic Gateway

Merrifield, Rob, P.C.

Minister of State to assist the Minister of Transport — Transport Crown Corporations to be styled Minister of State — Transport

Moore, The Hon. James, P.C.

Minister of Canadian Heritage to be styled Minister of Canadian Heritage and Official Languages

Nicholson, The Hon. Robert Douglas, P.C.

Minister of Justice and Attorney General of Canada

O’Connor, The Hon. Gordon, P.C.

Minister of State to assist the Prime Minister to be styled Minister of State and Chief Government Whip

Oda, The Hon. Beverley J., P.C.

Minister for International Cooperation to be styled Minister of International Cooperation

Paradis, The Hon. Christian, P.C.

Minister of Public Works and Government Services and Minister of the Economic Development Agency of Canada for the Regions of Quebec to be styled Minister of Public Works and Government Services

Prentice, The Hon. Jim, P.C.

Minister of the Environment and Minister of Western Economic Diversification to be styled Minister of the Environment

Raitt, Lisa, P.C.

Minister of Natural Resources

Ritz, The Hon. Gerry, P.C.

Minister of Agriculture and Agri-Food to be styled Minister of Agriculture and Agri-Food and Minister for the Canadian Wheat Board

Shea, Gail, P.C.

Minister of Fisheries and Oceans

Strahl, The Hon. Chuck, P.C.

Minister of Indian Affairs and Northern Development to be styled Minister of Indian Affairs and Northern Development and Federal Interlocutor for Métis and Non-Status Indians

Thompson, The Hon. Gregory Francis, P.C.

Minister of Veterans Affairs

Toews, The Hon. Vic, P.C.

President of the Treasury Board

Van Loan, The Hon. Peter, P.C.

Minister of Public Safety and Emergency Preparedness to be styled Minister of Public Safety

Verner, The Hon. Josée, P.C.

President of the Queen’s Privy Council for Canada and Minister of State to assist the Minister of Foreign Affairs to be styled Minister of Intergovernmental Affairs, President of the Queen’s Privy Council for Canada and Minister for La Francophonie

Yelich, Lynne, P.C.

Minister of State to assist the Minister of Western Economic Diversification to be styled Minister of State — Western Economic Diversification

November 7, 2008

JACQUELINE GRAVELLE
Manager

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DEPARTMENT OF INDUSTRY

OFFICE OF THE REGISTRAR GENERAL

Appointments

November 7, 2008

JACQUELINE GRAVELLE
Manager

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BANK OF CANADA

Balance sheet as at October 31, 2008

(Millions of dollars) Unaudited

I declare that the foregoing return is correct according to the books of the Bank.

Ottawa, November 7, 2008

H. A. WOERMKE
Acting Chief Accountant

I declare that the foregoing return is to the best of my knowledge and belief correct, and shows truly and clearly the financial position of the Bank, as required by section 29 of the Bank of Canada Act.

Ottawa, November 7, 2008

W. P. JENKINS
Senior Deputy Governor

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